Surface modification of electrospun polycaprolactone (PCL) fibers

The strong hydrophobicity of PCL lead to suboptimal cell interactions. Oxygen plasma treatment, wet etching using NaOH, and RGD immobilization were used to change the wettability of the fibers and enhance the cell attachment and proliferation.

 

PCL fibers after oxygen plasma treatment and NaOH etching (b) and (d), showing decreased contact angle and increased surface roughness.

 

Controlled release of ondansetron from electrospun PCL fibers

Oral delivery of ondansetron, a drug to prevent nausea and vomiting after surgery or chemotherapy, releases payload within minutes and can usually cause undesirable side effects. Electrospun PCL fibers are used to incorporate the drug for sustained release.

 

 

(A) Electrospun PCL patch incorporating ondansetron; (B) SEM image of the patch; (C) scanning transmission electron microscopy image showing inclusion of ondansetron in PCL; and (D) in vitro release of the ondansetron from the patch in PBS as analyzed by HPLC (n=5).

 
Collagen isolation from rat tails

A low-cost isolation process has been developed to extract and isolate collagen from rat tails. Collagen fibers show excellent cell adhesion and proliferation behaviour.

 

Electrospun collagen fibers shows good cell attachment and viability after 15 days in culture.

 

Orthopaedic/Dental materials

Development of a Finite Element Lumbar Spine Model to Predict Intervertebral Disc Herniation Risk This paper has been submitted for publication in the journal Spine and is part of LTU PhD Student, Stephanie Rossman’s Dissertation.

A Novel Osseous Densification Approach in Implant Osteotomy Preparation to Increase Biomechanical Primary Stability, Bone Mineral Density and Bone to Implant Contact. The seminal biomechanical validation study of Osseodensification, was published in the International Journal of Oral and Maxillofacial Implants with Dr. Salah Huwais, a practicing Periodontist, inventor and founder of Versah LLC.

 

LTU Faculty and Facilities

Yawen Li, PhD

Associate Professor, Biomedical Engineering

Active research projects include biocompatibility evaluation of nanocarbon materials and hot spring mineral water. Past research experience includes drug delivery microchip, liver tissue engineering, and retrovirus production on chip.

Michael G. Lancina III, PhD

Assistant Professor, Biomedical Engineering

Active research projects include in vitro production of natural biopolymers, primarily chitin. Past research experience includes developing targeted or active drug delivery vehicles from both natural and synthetic polymers, as well as investigating the biocompatibility of numerous novel materials.

Eric G. Meyer PhD, Director Experimental Biomechanics Lab

Associate Professor, Biomedical Engineering

Research interests combine in vivo testing of human and animal subjects with cadaver and surrogate in vitro models and computer simulations to understand normal health, acute injury and degenerative mechanisms. Collaborates with clinicians and the medical device industry to develop preventative and regenerative treatments for bone and soft tissue damage and disease.

Biomaterials Laboratory

Located in the new Taubman Complex, the Biomaterials Lab is equipped with a laminar flow hood, two fume hoods, two -80°C freezer, an autoclave, an incubator, a microtome, an electrosponner, and a laser cutter. 

Environmental Scanning Electron Microscope (ESEM) Laboratory

The ESEM Laboratory houses the FEI Quanta 450 FEG microscope with the following accessories: Peltier/Heating Stage (-20°C~1500°C), EDAX SSD EDS System (Genisis XM 4i), Denton Au/C Coater Desk V, and Gatan Tensile Stage (Deben MT300).

 

Center for Innovative Materials Research - multiple screw-axis, hydraulic and electro-mechanical testing machines that can be used for biomechanical testing. The many MTS/Instron materials testing machines have varying force/strain measurement capabilities and fixtures, including an ElectroPlus E1000, biaxial (tension/compression & torsion) electro-mechanical testing machine with Instron Advanced Video Extensometer.